Acyl bromides
TARGETMOL CHEMICALS INC Tarloxotinib bromide 1MG
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Tarloxotinib bromide (TH-4000) is an irreversible inhibitor of EGFR/HER2. Purity 97.15%
Medchemexpress LLC 4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone | 4551-69-3 | 99.9% | 278.31 | 1 G
4-Benzoyl-3-methyl-1-phenyl-5-pyrazolone is a heterocyclic compound featuring a five-membered ring structure. It serves as a versatile compound in scientific research.
- Can be used as a starting material for organic synthesis.
- Functions as a reagent for organic transformation.
- Acts as a biological probe for studying biological processes.
- Utilized as a biomaterial or organic compound for life sciences research.
Medchemexpress LLC (2e)-1-(3,4-dimethoxyphenyl)-5-fluoro-3-(4-fluorophenyl)-2-(2-fluorophenyl)pent-1-en-4-one bromide | 1390654-28-0 | >98.8% | 524.38 | 100 MG
KRN2 bromide is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. It selectively suppresses the expression of pro-inflammatory genes, including Nos2 and Il6, without hindering high-salt-induced NFAT5 and its target gene expressions. KRN2 also dose-dependently inhibits NF-κB p65 binding to Nfat5 promoter 1 and directly blocks the interaction between NF-κB p65 and its DNA binding sequence in the upstream site of Nfat5 exon 1.
- Effectively suppresses AIA in which innate immune cells play a predominant role.
- Effectively suppresses CIA as well as AIA in mice.
- Decreases the production of pro-inflammatory cytokines and autoantibodies.
- Reduces macrophage infiltration.
Apexbio Technology LLC Aclidinium Bromide 320345-99-1 100mg
Aclidinium Bromide (CAS 320345-99-1) is a long-acting muscarinic antagonist (LAMA) that selectively inhibits muscarinic acetylcholine receptors In binding assays it demonstrates high affinity for M1 M5 receptor subtypes with Ki values of 0 10 0 21 nM Functional studies reveal greater potency at endogenous M2 and M3 receptors with EC50 values of 17 4 nM and 5 3 nM respectively In vivo aclidinium bromide produces a concentration-dependent inhibition of acetylcholine-induced bronchoconstriction (EC50 2 5 23 1 g/mL in anesthetized guinea pigs) and suppresses pilocarpine-induced salivation in rats (EC50 38 g/kg) This compound is widely utilized in respiratory research for evaluating airway smooth muscle modulation via muscarinic receptor antagonism
Apexbio Technology LLC Aclidinium Bromide 320345-99-1 50mg
Aclidinium Bromide (CAS 320345-99-1) is a long-acting muscarinic antagonist (LAMA) that selectively inhibits muscarinic acetylcholine receptors In binding assays it demonstrates high affinity for M1 M5 receptor subtypes with Ki values of 0 10 0 21 nM Functional studies reveal greater potency at endogenous M2 and M3 receptors with EC50 values of 17 4 nM and 5 3 nM respectively In vivo aclidinium bromide produces a concentration-dependent inhibition of acetylcholine-induced bronchoconstriction (EC50 2 5 23 1 g/mL in anesthetized guinea pigs) and suppresses pilocarpine-induced salivation in rats (EC50 38 g/kg) This compound is widely utilized in respiratory research for evaluating airway smooth muscle modulation via muscarinic receptor antagonism
Medchemexpress LLC QX-314 (bromide) | 24003-58-5 | MFCD00083182 | 96.6% | 343.30 | C16H27BrN2O | 1 ML
QX-314 bromide is a membrane-impermeable, permanently charged sodium channel blocker provided as a ready-to-use 10 mM solution in DMSO or as a solid for reconstitution. It is commonly used in electrophysiology and neurophysiology experiments to selectively block intracellular voltage-gated sodium channels during recordings and manipulations.
- Membrane-impermeable quaternary lidocaine derivative.
- Available as 10 mM solution in DMSO or solid for reconstitution.
- Used to block intracellular voltage-gated sodium channels in electrophysiology.
- CAS number 24003-58-5 for unambiguous identification.
- Supplied with reported purity suitable for research applications.
Apexbio Technology LLC Mepenzolate Bromide 76-90-4 10mM (in 1mL DMSO)
Mepenzolate bromide (CAS 76-90-4) is a synthetic quaternary ammonium compound that functions as a muscarinic acetylcholine receptor antagonist By inhibiting parasympathetic neural transmission it reduces gastric secretion and gastrointestinal motility Mepenzolate bromide is generally supplied as a white to light cream powder with high solubility in methanol limited solubility in water and chloroform and minimal solubility in ether This compound is widely employed in research investigating modulation of cholinergic signaling gastrointestinal physiology and autonomic pharmacology and serves as a tool compound for studying antimuscarinic mechanisms in vitro and in vivo
Medchemexpress LLC Biotin-PEG3-bromide | 1041766-91-9 | 95.0% | 482.43 g·mol⁻1 | C18H32BrN3O5S | 25 MG
Biotin-PEG3-bromide is a biotinylated short polyethylene glycol (PEG3) linker with a terminal alkyl bromide. It is used to introduce a biotin affinity tag onto molecules via nucleophilic substitution or cross-coupling reactions, enabling streptavidin-based capture, detection, and pull-down workflows in chemical biology and bioconjugation studies.
- Reactive alkyl bromide suitable for nucleophilic substitution and cross-coupling reactions.
- Biotin moiety enables high-affinity capture with streptavidin/avidin reagents.
- Short PEG3 spacer improves solubility and reduces steric hindrance.
- High solubility in DMSO allows preparation of concentrated stock solutions.
- Powder stable at -20°C; follow recommended storage for solutions to maintain integrity.
Medchemexpress LLC Umeclidinium bromide | 869113-09-7 | MFCD18782614 | 508.49 | 1 G
Umeclidinium bromide is a novel mAChR antagonist, demonstrating high affinity for cloned human M1-M5 mAChRs with Ki values ranging from 0.05 to 0.16 nM. It is a potent agent that exhibits slow functional reversibility at cloned human M3 mAChRs and endogenous mAChRs in isolated human bronchus. This compound is suitable for research in various disease areas including neurological, eye or ear disease, cancer, inflammation or immune system disease, neurodegenerative disease, and Parkinson's disease.
- Novel mAChR antagonist
- High affinity for human M1-M5 mAChRs (Ki 0.05-0.16 nM)
- Inhibits human ether-a-go-go-related gene channel tail current with an IC50 of 9.4 μM
- Demonstrates slow functional reversibility at human M3 mAChRs
- Applicable for research in neurological, ocular, oncological, inflammatory, and neurodegenerative conditions
Medchemexpress LLC Mepenzolate bromide | 76-90-4 | 99.9% | 420.34 | 100 MG
Mepenzolate bromide is an orally administered muscarinic receptor antagonist with Kis of 0.68 and 2.6 nM for hM2R and hM3R, respectively. It can be used to suppress gastrointestinal hypermotility associated with irritable bowel syndrome. Mepenzolate bromide is also a GPR109A inhibitor.
- Muscarinic receptor antagonist
- GPR109A inhibitor
- Exerts anti-inflammatory effect via a muscarinic receptor-independent mechanism
- Bronchodilatory effect via a muscarinic receptor-dependent mechanism
- Subtype-non-specific muscarinic antagonist
- Beneficial effects in a mouse model of chronic obstructive pulmonary disease (COPD)
Medchemexpress LLC N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine | 67219-55-0 | 98.9% | 633.69 | 5 G
N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine, also known as 5'-O-DMT-N4-Bz-dC, is a compound that can be used for the synthesis of oligodeoxynucleotides containing a 3'-S-phosphorothiolate (3'-PS) linkage. It serves as a useful tool for probing enzyme-catalyzed cleavage processes in DNA.
- Used for synthesis of oligodeoxynucleotides.
- Useful tool for probing enzyme-catalyzed cleavage processes in DNA.
Medchemexpress LLC Cimetropium Bromide | 51598-60-8 | 438.36 | 10 MG
Cimetropium Bromide (DA-3177) is a muscarinic acetylcholine receptor (mAChR) antagonist used for the long-term treatment of irritable bowel syndrome. It is a competitive antagonist of muscarinic-mediated contractions in isolated colonic preparations. In vivo, it acts as a potent inhibitor of large bowel motility.
- Used for long-term treatment of irritable bowel syndrome
- Competitive antagonist of muscarinic-mediated contractions
- Potent antimuscarinic effect in inhibiting longitudinal muscle contraction
- Potent inhibitor of large bowel motility evoked by exogenous and endogenous stimuli